LAMP1 anticorps

N° du produit ABIN7091346

Cet anticorps Souris Monoclonal détecte spécifiquement LAMP1 dans WB, IF et ICC. Il présente une réactivité envers Humain.

Aperçu rapide pour LAMP1 anticorps (ABIN7091346)

Antigène: LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LAMP1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: A7D12

Détail du produit anti-LAMP1 anticorps

Réactivité croisée: Humain

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human LAMP1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IF()
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur LAMP1

Antigène: LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))

Autre désignation: LAMP1

Sujet:

Synonyms: CD107 antigen like family member A, CD107 antigen-like family member A, CD107a, CD107a antigen, LAMP 1, LAMP-1, LAMP1_HUMAN, LAMPA, LGP120, lgpA, Lysosomal membrane glycoprotein 120KD, Lysosomal Associated Membrane Protein 1, Lysosome associated membrane glycoprotein 1, Lysosome-associated membrane glycoprotein 1, Lysosome-associated membrane glycoprotein 1, Lysosome-associated membrane protein 1, OTTHUMP00000040663.

Background: Lysosome associated membrane protein (LAMP1), also known as lgp120 or lgpA, is a type 1 integral membrane protein that is transported from trans Golgi networks to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboxyl terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1. This mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation.

ID gène: 3916

UniProt: P11279

Pathways: Autophagy